Exogenous Ketones: A Shortcut to Therapeutic Ketosis for Chronic Fatigue
What Are Exogenous Ketones?
Exogenous ketones provide a convenient way to achieve the benefits of ketosis without adhering to a strict ketogenic diet. These supplements increase blood levels of β-hydroxybutyrate (BHB), a ketone body that enhances energy production, reduces oxidative stress, and modulates inflammation. This makes them particularly appealing to those with chronic fatigue, neurodegenerative conditions, and others seeking the therapeutic advantages of ketosis.
How Do Exogenous Ketones Work?
Available in forms such as ketone salts, ketone esters, and medium-chain triglycerides (MCTs), these supplements aim to elevate BHB levels in the blood and brain. Ketone esters are the most potent, providing a sustained increase in BHB, followed by ketone salts and MCTs. Their effects include improved mitochondrial function, reduced glycolysis, and anti-inflammatory benefits.
Research Highlights:
Ketone Esters vs. Ketone Salts: A 2017 study found that esters increased BHB levels 50% more effectively than salts, offering longer-lasting effects.
Alzheimer’s Study: A drink containing 40g of emulsified MCTs improved memory recall in Alzheimer’s patients, correlating with elevated BHB levels.
Side Effects: Some studies report gastrointestinal discomfort, especially with higher doses of esters, though these effects are transient and manageable.
Can You Eat Carbs and Take Exogenous Ketones?
Yes, but results improve with reduced carbohydrate intake. While traditional ketogenic diets cap carbohydrates at 10-15% of daily calories, exogenous ketones can allow for a more flexible low-carb approach, with carbs constituting up to 30% of caloric intake.
Choosing the Right Ketone Product:
Best for Results: HVMN Ketone Ester and KE4 offer the most effective BHB elevation but come at a premium cost.
Balanced Option: KetoForce and GoBHB are high-quality ketone salts available at a moderate price point.
Budget-Friendly: Pure C8 by KetoSource is a reliable MCT option for those seeking benefits at a lower cost.
How to Use Exogenous Ketones:
Start with small doses to minimize gastrointestinal discomfort.
Gradually increase intake to reach tolerance.
Consume supplements on an empty stomach, away from meals, and pair with a low-carb diet for optimal results.
Why Try Exogenous Ketones?
They provide a practical, research-backed method to enjoy the cognitive and energy-boosting benefits of ketosis without the strict compliance required by traditional ketogenic diets. Whether you’re managing chronic fatigue, brain fog, or simply seeking enhanced energy, exogenous ketones are a promising tool to add to your wellness routine.
References
Kovács Z. et al (2019) Therapeutic Potential of Exogenous Ketone Supplement Induced Ketosis in the Treatment of Psychiatric Disorders: Review of Current Literature. Front Psychiatry. 10:363.
Stubbs BJ, et al (2017) On the Metabolism of Exogenous Ketones in Humans. Front Physiol. 8:848.
Hashim SA & VanItallie TB (2014) Ketone body therapy: from the ketogenic diet to the oral administration of ketone ester. J Lipid Res. 55(9):1818-26.
Achanta, L. B., & Rae, C. D. (2016). β-Hydroxybutyrate in the Brain: One Molecule, Multiple Mechanisms. Neurochemical Research, 42(1), 35–49.
